The One Health approach, an interconnected approach to health that recognises the interdependence of people, animals, plants and ecosystems, is gaining traction in Europe. Today, 13 November, the European Commission is organising a conference to discuss the future of One Health policy in Europe. Several EU agencies have also expressed their joint commitment to fully support the One Health agenda to better prevent, prepare for and respond to global health threats at global and EU level, including those related to climate change. Europe is facing increasingly complex and frequent threats to health and well-being. Many of these threats are linked to unsustainable patterns of production and consumption and serve as a stark reminder that human health is closely linked to the health of animals, plants and ecosystems. No individual discipline or sector acting in isolation can respond to these threats. The urgent need for multisectoral and transdisciplinary collaboration in the areas of human, animal, plant and ecosystem health is captured by the One Health approach.